The QX600 AutoDG Droplet Digital PCR System (ddPCR) offers workflow automation, delivers advanced six-color multiplexing, and absolute quantification of nucleic acid without sacrificing the best-in-class performance you have come to expect from Bio-Rad’s ddPCR systems.
The AutoDG Instrument eliminates user-to-user variability, allowing you to fully exploit the precision of ddPCR technology by providing more consistent droplet counts across users and plates. The AutoDG Instrument also minimizes hands-on time — it takes less than 5 minutes to load the instrument, and no supervision or user activity is required during droplet generation.
Benefits of the QX600 AutoDG Droplet Digital PCR System
The Automated Droplet Generator offers:
- A simplified ddPCR workflow
- Generates droplets for up to 96 ddPCR samples in under 45 minutes
- Compatibility with QX200™ reagents and consumables
- Guided setup and loading with user-friendly touch-screen interface
- Run-to-run flexibility with user-definable plate layout in 8-well increments
- Reduced contamination risk with HEPA-filtered enclosure allowing the system to be placed in any lab environment
The QX600 Droplet Reader offers users:
Sensitive multiplexing
- Six-color detection capability (FAM, HEX, Cy5, Cy5.5, ROX, and ATTO 590)
- Quantification of up to 12 targets in a single well
- Absolute quantification with 0.1% or better sensitivity
- Sensitive and precise gene expression multiplexing
Accurate and reproducible results
- Confidence in your results bolstered by a system qualified by standards from National Measurement Institute (NMI), Australia
- Sets the standard for reproducibility as demonstrated in numerous studies
Powerful software
- User-friendly analysis
- Audit trails and tools for U.S. FDA 21 CFR Part 11 compliance with premium edition
- Assay protocol files for automated data analysis and reporting with premium edition
- Portfolio compatibility
- Cross-compatibility with QX200 reagents, assays, and consumables
- Extensive menu of pre-existing ddPCR assays
- System capable of running both TaqMan® and EvaGreen chemistries
Applications of the QX600 Droplet Digital PCR System
The QX600 System enhances a wide variety of applications, including: oncology research, gene expression, next generation sequencing (NGS) orthogonal testing, cell and gene therapy, food and wastewater testing.
Oncology research — The QX600 System collects more information per well, preserving precious circulating tumor DNA (ctDNA) and tumor samples.
- Structural variant analysis
- Rare variant detection
- Copy number variation
- Methylation detection
- Loss of heterozygosity
Gene Expression: Employ the extreme precision of the QX600 System to quantify small-fold changes in low abundance RNA molecules.
Next generation sequencing (NGS) orthogonal testing: With the QX600 System perform accurate quantification and qualification of NGS libraries without the use of a standard curves.
- Cell and gene therapy: Accelerate therapeutics discovery with highly-advanced multiplexing afforded by the QX600 System.
- Residual DNA detection in biologics
- Genome edit confirmation
Food testing: Use the QX600 System to perform routine evaluation of genetically modified organisms (GMO) and pathogen contamination detection.
Wastewater testing: Leverage the QX600 System to perform population-wide monitoring of established and emerging pathogens.